Pyroluria

I just got my test results back from Direct Health Care Access II (http://www.pyroluriatesting.com/). Results were 80 for the normal vial, 50/37 (?) for the adjusted vial. Normal ranges, 0-10 normal, 10-20 slightly elevated, 20+ pyroluria.

Pyroluria is genetic and causes those with it to urinate their Zinc/B6, making the sufferer deficient.

A lot of my symptoms align with it (fatigue, light sensitivity, inability to excrete metals, dark circles, worn adrenals, unexplained diffuse hair loss, etc).

So we'll see how it goes. Treatment is usually Zinc, B6, Mg, Ms, and Primrose Oil.


Do you tan?

http://www.wellbeingjournal.com/nutrients.htmPyrrole Disorder

A common feature of many behavioral and emotional disorders is pyroluria, detectable as a purple (on testing paper) metabolite in urine called the mauve factor. Pyroluria is an inborn error of pyrrole chemistry, which results in a dramatic deficiency of zinc, vitamin B-6 and arachidonic acid (an omega-6 fatty acid). Certain pyrroles called kryptopyrroles (literally, hidden pyrroles) bind with B-6, then zinc to deplete the body's supply. Common symptoms include explosive temper, mood swings, poor short-term memory and frequent infections. These patients are easily identified by their inability to tan, poor dream recall, abnormal fat distribution and sensitivity to light and sound. The decisive laboratory test is analysis for kryptopyrroles (the mauve factor) in urine. Treatment centers on zinc and B-6 supplements together with omega-6 essential fatty acids.

Here's what he has to say...First, from page 10...

http://neuraltherapy.com/LymeALookBeyond6.pdf

"Many Lyme patients suffer from Pyrroluria, a metabolic illness where
abnormal porphyrins carry out significant amounts of needed zinc and
vitamin B6. Diagnosis is made with the appropriate test at the Pfeiffer
institute in Chicago. Even though it is assumed that this illness is hereditary
I have my doubts, since most Lyme sufferers have a degree of it. I suspect
that the appearance of kryptopyrroles in the urine is induced by the illness.
However, I am careful with excessive substitution of zinc. Zinc has a
synergistic effect with mercury in the brain and also promotes the growth of
the herpes viruses."

Second, from page 32...

Practical Considerations and Recipes:
Neuroborreliosis:
o read and understand the Klinghardt Neurotoxin Elimination
Protocol
o bee venom therapy is superior

o most patients have a degree of kryptopyrroluria (excretion of
abnormal hemoglobin breakdown products) which leads to a loss of
excessive amounts of zinc, B6, and Omega 6 fatty acids. It is
recognized by either ART testing or by finding a low or low normal
alkaline phosphatase (below 50). Replace zinc, copper, Magnesium,
B6 (I ask the client to increase the amount until he/she has vivid
dreams regularly) Niacin (work up to 3000 mg/day) and Udos oil.

o Do not give zinc without copper in Lyme!
o Use KMT to vagus, spheno-palatine ganglion and superior cervical
ganglion. Always use Rechtsregulat to reach microcirculation.
o Always use BioPure Phospholipid Exchange.
o In Bells palsy use Stephania root.1 tsp t.i.d.
o At least 2/3rds of clients with Bb also have a Babesia co-infection
which has to be treated early.
o Use polygonum, smilax and andrographis early on
o Use neural therapy, especially in the ganglia together with glutathione
or DMPS


"Promotes growth of herpes virus"

What if you don't have it?


>> "Promotes growth of herpes virus"

>> What if you don't have it?

There are a HUGE number of viruses in the herpes family. Dr. K claims the vast majority of his lyme patients have HHV-6, which suppresses multiple components of the immune system, making things MUCH worse for lyme patients. Numerous doctors also seem to believe that HHV-6 may be a necessary cofactor in AIDS.

Epstein Barr virus is also a member of the herpes family, and common in lyme patients. I tested positive for 3 strains of EBV, and my HHV-6 antibodies were 17 times reference.

http://www.mult-sclerosis.org/HerpesViruses.html



It's a chicken and egg scenario. Pyroluria was first recognized in the 1950's I believe. So I don't think it's necessary a result of lyme, as many have pyroluria without lyme. Perhaps those with pyroluria have a harder time beating lyme? I know some people that have had lyme, take the course of antibiotics, and go on their merry way.


>> It's a chicken and egg scenario.

I don't think Dr. K is necessarily suggesting lyme is absolutely necessary for pyrroluria. He is doubting though that it's purely genetic, given that so many lyme patients have it. The most important question here is how much does it influence our ability to heal from lyme imo. Perhaps it's a quite important for all of us.

>> Pyroluria was first recognized in the 1950's I believe.

Interesting you date it to the 50's. Dr. K claims borrelia can be dated to at least the 60's and perhaps the 50's.

======

"Other authors suggest that different subtypes of Borrelia, which cause illness
in humans, such as B. afzelii and B.garinii have probably existed longer then
B.burgdorferi and occur naturally (1, 2) and have been with us for a long
time, maybe centuries or much longer then that.
Neurologist Prof. J. Faust MD, PhD of the Albert-Ludwig University in
Freiburg, Germany (3) related many neurological and psychiatric illnesses to
spirochete infections as early as the 1960s. He was so skilled in his clinical
knowledge that he could based on clinical neurological symptoms
accurately predict which valley in the Black Forest the infected patient was
from! This clearly was a time before Bb - showing that non-syphilis
spirochete infections were around earlier then the famous Bb outbreak in
Connecticut in the mid seventies. It also makes a strong statement to the fact
how easily these creatures may mutate and adapt to local conditions. It may
however validate the findings published in Lab 257: Tuebingen, the place
where German/US warfare spirochete expert Traub was continuing his
spirochete experiments in the early 50s, is situated in the Black Forest also.
Were these spirochetes genuine or have they escaped from a university
laboratory?"

======

>> So I don't think it's necessary a result of lyme, as many have pyroluria without lyme.

Perhaps not, but who knows. If lyme can induce it then that's important.

>> Perhaps those with pyroluria have a harder time beating lyme?

I would bet that it does.

>> I know some people that have had lyme, take the course of antibiotics, and go on their merry way.

I also had dinner on saturday night who took abx in response to a the tick bite rash, went on her merry way for several years, but relapsed. Lyme sucks!

Do are you questioning your lyme dx?


Ro

Indeed. I don't think they have to go together. But those who took ax and went on their merry way are usually those who caught it early.

Didn't you test positive for lyme?

Let us know how you feel after your treatment!

Yes I did. dpd, not doubting lyme at all, just not sure which came first, you know? I've had symptoms all my life, so who knows.

Definitely going to keep fighting lyme, mainly with Salt/C, and also addressing pyroluria and metals.


Heavy metals seem to also cause pyrroluria.


Rob,

How are you feeling these days? How's the s/c going? How much are you taking?


as part of the list of supps you provided?

>> So we'll see how it goes. Treatment is usually Zinc, B6, Mg, Ms, and Primrose Oil.


Probably meant Mn, or Manganese