Cimetidine

Its quite clear that with myself as with many others drugs will only take you so far towards a cure. Its a medical fact that the immune system eventually becomes too stressed with long-term infections to be effective. We develop an Anergy [the opposite of allergy] towards long-term [chronic] infections.
On researching immunomodulators I came across Cimetidine,I am currently taking the drug ,Its known as Tagamet in the US, its safe cheap easily obtained and judging by how I react to it very effective .Im just into my second week at 400 per day, .Im not treating yeast BTW but co-infection[s] Paul


Ann Intern Med. 1980 Feb;92(2 Pt 1):192-5. Related Articles, LinksCimetidine as an immunomodulator: chronic mucocutaneous candidiasis as a
model.

Jorizzo JL, Sams WM Jr, Jegasothy BV, Olansky AJ.

Four adult patients with chronic mucocutaneous candidiasis were studied to
establish a possible role for cimetidine as an immunomodulator. These
patients had negative baseline in-vivo and in-vitro cell-mediated immune
response to candida antigen as measured by intradermal skin tests,
lymphocyte transformation, and leukocyte migration inhibitory factor
production to cimetidine, 300 mg by mouth, four times daily. Subsequently
four of four patients developed strong (greater than 15 mm) intradermal skin
test reactions, and two of four patients produced leukocyte migration
inhibitory factor to candida antigen. Skin tests and leukocyte migration
inhibitory factor production reverted to baseline negative values when
repeated 4 weeks after discontinuation of therapy. After 4 additional weeks
on cimetidine, four of four patients showed strong positive skin tests and
leukocyte migration inhibitory factor production to candida antigen.
Lymphocyte transformation was not affected by therapy.

PMID: 7352725 [PubMed - indexed for MEDLINE]

Polizzi B, Origgi L, Zuccaro G, Matti P, Scorza R.
> >
> > Institute of Internal Medicine, Infectious Disease and
> Immunopathology,
> > Univerity of Milan, Italy.
> >
> > The authors evaluated the clinical efficacy of a treatment with
> cimetidine
> > and zinc sulphate in a patient with chronic mucocutaneous
> candidiasis.
> > Cimetidine was given at a dose of 400 mg three times daily; zinc
> sulphate at
> > a dose of 200 mg daily, then adjusted to maintain blood zinc
> levels at the
> > upper normal range. This treatment lasted 16 months. An impressive
> and
> > significant reduction of the infectious events and an increased
CD4
> > (helper/inducer) cell counts were observed. The authors conclude
> that this
> > combined immunopotentiating treatment is safe and inexpensive to
> treat
> > immunodeficiency disorders.
> >
> > Publication Types:
> > Case Reports
> >
> > PMID: 8602650 [PubMed - indexed for MEDLINE]
> >
> > Chronic mucocutaneous candidiasis in a 6-year-old boy
> >
> > http://jmii.org/content/pdf/v37n3p196.pdf


Hi Paul,

Interesting post. Not sure I agree with the idea that long term infections cause immune system deficiency. In my experience its the other way around....immune deficiency causes long term chronic illness, which further weakens the immune system.

In my case and that of my daughter, immune deficiency was caused by xenobiotics, which caused a deficiency of CD4 cells and an over expression of CD8 cells.

Both of us suffered from Candidiasis, seemingly as a result of our weakened immune systems.

Once we identified and eliminated the xenobiotics (Mercury in my case, pesticides in my daughter's), our immune systems recovered and the Candida, once treated with AFs, did not return.


Hi Steve , either which way!! I am familiar with your story & an immune deficiency through zenobiotics is certainly one way of contracting yeast But .Zenobiotics is not the only factor that brings about an immune deficiency.
Antibiotics that shift the balance of microbes in the gut to favour fungi is the main rout to yeast infection ..The downgrading of liver enzymes by the metabolites of yeast set us on the slippery slope that leads to IS downgrading.

.In this case metals accumulate after the fact not before yeast.

Long term infection will indeed stress the IS to the point that it fails to respond it is a medical factas explained to me by an immunologist no less. You may read Cranton again , he explains the condition . Or search anergy its not a fringe opinion.
I have some other interesting stuff on crimetidine , It looks like it very well could re-set the IS.
Histamine could be the catalyst that sends the IS into an allergic TH2 response. Whilst in the th2 mode bugs are well hidden ..Using a h2 antagonist blocks the action ..[ I think] ..ill be glad to share ,if you or anyone is interested..Paul

Hi Paul,

I agree with a most of your points. Certainly antibiotics or hidden allergies can lead to long term IS damage. Nor do I dispute that chronic illness damages the immune system...that's what happened to me...my only point is that in order to have to have chronic illness like yeast, there must already be something wrong with the immune system in order for the yeast to become chronic, which would be the role of the antibiotics, hidden allergy, xenobiotics etc. If that's true, then no amount of IS modulation is going to effect a cure until the original problem is resolved



Hmm, seems to be a bit of a contradiction there .If you agree that abxs are a cause then once the balance of gut flora is shifted to favour fungi ,the genie is out of the bottle so to speak. Abx therapy the original problem is not a lingering condition that needs to be addressed in order to clear the decks ready for any effective treatment.
So I dont agree with your point that there must be something wrong with the IS to acquire a yeast infection .
I do agree that its not much use tweaking the IS when the drivers of any induced dysfunction are still in place But CMC is a serious condition , its generally thought to stem from a genetic fault with the IS , to cure as per the extract is remarkable. ..Paul



Hi Paul,

Again I don't disagree with you but I am finding this debate interesting.

I agree that ABX overuse can trigger yeast, but the question still remains, what caused the need for so many ABXs...more than likely its a recurring infection, due to an already impaired IS. One day on a plane I met a young man with very bad acne and CFIDS. He'd had acne since a young age and had taken mega loads of antibiotics, which had helped but not cured the acne. The discussion lead to finding out that he loved to build and paint airfix models of aeroplanes and cars. His room was full of models, which he'd painted himself. He noted that he often felt unwell due to the paint fumes. More than likely what he was really suffering from was chloracne, caused by the chlorinated solvents used in the paint and glue. His Doctor had prescribed the ABXs, which damaged his gut flora and allowed Yeast to overrgrow. The combination of IS damage from the solvents and overload from the yeast started a spiral of chronic illness. In order to recover, he would need to suppress the yeast, stop using chlorinated solvents and get rid of many of the recently finished models that were still releasing solvents into his environment. Once relieved of its toxic load, IS therapy could well effect a permanent cure.


Yes the deteriorating health of western societies despite billions being spent on health care.. I think your right in one sense but to get the whole picture we need to stand back and take in info from a number of sources. We should be able to tolerate some level of toxins metals or otherwise , the fact that allergys are increasing explosively along with Asthma and all the other so called auto immune diseases tells us there something up .Now consider the fact that the Amish society has no Asthma no Autism hardly any of the autoimmune diseases in fact
They have removed from their environment the factors that cause the conditions . Autism, yeast, lyme are all connected as is all the auto immune ..Read my site click the bold in the text & look up the referencesIt is the explanation I assure youPaul

http://www.yeast-candida-infections-uk.co.uk/



Hi Paul,

I realise we're getting well off the original topic, but I am enjoying the dialog.

Think of a downward spiral....you've mentioned all the elements:
Liver detoxification
Intestinal flora
Heavy metals and xenobiotics
Immune system

Intestinal flora is part of the immune system. Lets start somewhere and say that the flora is damaged by ABXs. In the absence of the correct flora, proteins are incorrectly broken down, forming highly bioactive peptides, which increase gut permiability, which in turn allows peptides to pass through the intestinal walls and into the bloodstream, where they trigger the immune system. At the same time, yeast fills the vacuum once occupied by the healthy bacteria, changing the gut's pH and altering the millieu from healthy digestion to anaerobic putrification. Vitamins and minerals are no longer conjugated by healthy bacteria and become depleted. Toxins from the yeast are absorbed into the blood stream and must be conjugated in the liver, along with used hormones, byproducts of digestion and a host of xenobiotics encountered in everyday life. The lack of minerals and vitamins and the excess load on the liver soon means that the liver's detoxification pathways start to falter and toxins build up in the blood and tissues. Hormones that should be removed from the blood no longer are and endocrine system imbalances result. The immune system encounters an increase in toxins and is triggered 24x7x365. Instead of being removed by the liver, xenobiotics start to accumulate. As the body becomes more toxic, the immune system becomes increasingly less effective and allows yeasts and gram negative bacilli to grow unchecked in the gut.
The result is a spiral of chronic illness, malnutrition and a build up of toxic substances. Instead of being removed, Xenobiotics circulate through the body and bind to cell membranes, where they continue to trigger immune response, ultimately generating auto-immune disorders

Opiopeptides, formed by the incomplete digestion of Casein and Gluten leak into the blood circulation and are transported to the brain, to cause brain fog and concentration problems. Xenobiotics build up to cause radical mood alterations....depression and anxiety. Yeasts in the gut release toxins and capture carbohydrates and iron, resulting in poor sleep patterns, profound fatigue, anemia, hair loss, etc. etc. Food intolerances, allergies and a variety of complex syndromes are the ultimate result.



Yes you give a good description of an individuals slide into yeast-induced dysbiosis. But what about the general population , what about the autistic kids whos parents suffer disproportionately with auto-immune conditions ..Its the accumulative effect of poor gut flora , gut flora that is passed from mother to baby that is weakening the immune systems of the general populationThe adaptive IS is acquired from mothers gut flora the mucus & faecal material consumed at birth is actually seeding the infants gut .. Your as healthy as your gut flora lets you be ,it is the basis of the IS ..