Lyme
Polly,I was wondering if you could interpret this for me, please? I found it on a Lyme board and it pertains to the choline. I didn't know that Lyme used choline. If we supplement, it may be a problem.
Most of our worse bacterial infections are gram negative (the exception is anthrax). They have multiple cell walls.
To lyse (break apart) a gram negative pathogen involves several steps.
1. Damage or destroy the cell wall or *prevent it's formation in the first place*.
Bb's cell wall is UNIQUE! This is a unique pathogen. That is why traditional abx. aren't working.
However:
We KNOW that Bb needs choline. IF it's outer wall contains that mentioned below, it may hint that halting VLDL (very low density lipoproteins) release from the liver (via INactivating HMG CoA reductase) could be extremely important.
"Preliminary experiments suggested a stoichiometric interaction between P-choline-binding protein and VLDL. Hydrophilic P-choline groups exposed on the surface of VLDL may possibly interact with the P-choline- binding protein and thereby affect the precipitation of lipoproteins by heparin and Ca2+."
http://www.jbc.org/cgi/content/abstract/256/14/7440Stoichiometric means: Calculation of the quantities of chemical elements or compounds involved in a chemical reaction.
Or: a stoichiometric reaction, i. e., a reaction which goes to completion, rather than stopping partway at an equilibrium point.It sure looks like INactivating HMG CoA reductase AND INactivating PFK simultaneously would indeed do in this pathogen.
Now this is off the wall, but...If this pathogen wants choline...what if we give it plenty...ongoing? "Lure" it into the blood stream and digestive system where yeast (which bind zinc) can "dispose" of it?
Since lyme patients are already acidic, the idea of displacing Hg via selenium instead of trying to dissolve it with acids looks to be more appealing, given the need for this antioxidant anyway. How much, how often? With vitamin E at mealtimes?
(Once displaced, it is important to eliminate Hg so it is not recirculated, hence the importance of the nutrients needed to make bile.)
IMO...our body showed us from the "get go" what it needed to fight. Mg came "off" ATP and went into general circulation. Not Mg citrate or Mg sulfate...or any other compound. JUST Mg.
Now, the Romanian doctors did cure TWO EARLY onset lyme patients via large IV doses of a Mg compound (I do not know which one), but the fact that they did, is very interesting!
Mg is needed to make HEALTHY antibodies...along with Ca.
Mg is needed to INactivate PFK.
Mg is needed to INactivate HMG CoA reductase.
Mg is an anti-inflammatory.
The list goes on.
I don't think we had enough to "spare" fast enough.
IF abx. are indeed "anti-inflammatory" they have to be working one of 2 ways. Either they are alkaline or are acidic enough to "downregulate" other acid(s) TNF alpha. Since we are told they deplete minerals and some vitamins, that would look like they are "acidic".
Normally acidic things (negative charges) DO rid all pathogens and do destroy infected cells (radiation for cancer, for example).
What this all boils down to is: we need to look closely at what Bb is doing, what it needs and the paths it is taking, as well as how our body is responding to fight, and APPLY that knowledge to figure out a way to stop it.
Pace, this is all over my head. What does seem great is that the magnesium is helpful. Are you saying that Lyme uses the VLDP to make its shell?As for not adding in choline, you could follow the suggestions of Joeseph Burrascano, Jr., M.D. He suggests Lyme patients try SAM-e and Acetyl L- carnitine. This should increase the production of acetylcholine. He states
�ACETYL-L-CARNITINE- this is taken along with SAM-e. This combination can result in noticeable gains in short term memory, mood and cognition. The Acetyl Carnitine also is said to help heart and muscle function. Doses: Acetyl-L-carnitine- 1500-2000 mg daily on empty stomach. SAM-e- 400 mg daily with the acetyl-carnitine. Available in most vitamin stores. Positive results may appear as early as 3 weeks; use for 2 to 3 months. May be repeated if needed; generics are okay.�
http://www.lymenet.org/drbguide200509.pdf
ADVANCED TOPICS IN
LYME DISEASE ----
DIAGNOSTIC HINTS AND TREATMENT
GUIDELINES FOR LYME AND OTHER
TICK BORNE ILLNESSES
Fifteenth Edition
Copyright September, 2005�
