Diflucan

My Dr. is putting me on Diflucan (200mg)1 per day for 60 days and Nystatin liquid at the same time. Is this going to be to hard on the liver?

I know this has come up before. I will check the archives also


On the subject of the safety of antifungal meds in particular Fluconazole , read the following extract,Its part of The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review The document is very much worth reading. Note the dosage for systemic Candida infections, up to 400mg per day . Later studies recommend that the dose start at 400mg The optimal dose quoted is between 400 & 800mg per day .
http://jac.oupjournals.org/cgi/content/full/44/4/429

Fluconazole Saftey
Fluconazole is generally well tolerated over a wide dose range. 7 ,82 ,83 ,84 Clinical experience is extensive, with over 16 million patient-days of treatment with fluconazole since its introduction in the UK, and 300 million patient-days world-wide. The incidence of side effects is low, and symptoms are generally mild and do not require discontinuation from therapy.7 The most common side effects are associated with the gastrointestinal tract (nausea, abdominal discomfort, vomiting, diarrhoea). Others include headache and rashes, but these are rarely encountered (incidence of <2%). Tolerability is high even in special patient groups including children and severely ill patients with AIDS or cancer.7,85
Although not licensed, high doses of fluconazole (up to 800 mg/day) are well tolerated in the treatment of immunocompromised patients with severe systemic mycoses.86,87 Doses of up to 1600 mg fluconazole have been shown to be well tolerated in studies of AIDS patients with histoplasmosis88 and cryptococcal meningitis.83,87
In rare cases, particularly in patients with serious underlying diseases such as AIDS and cancer, abnormalities of hepatic, renal, haematological and other biochemical function tests have been observed, but the clinical significance and relationship of these to treatment is uncertain.7 Very rarely, post-mortem examinations of patients who died with severe underlying disease and had received multiple-dose fluconazole therapy have revealed hepatic necrosis: an assessment of the riskbenefit ratio of continued fluconazole administration for patients in whom a significant rise in liver enzymes occurs is, therefore, recommended. 89 ,90

Safety profile with children
http://pharmainfo.net/displayarticle10358.html


Is this your first experience with prescription antifungals? Make the most of the experience. You will most likely have strong cravings. Try your best not to give in. These prescription antifungals lose their effectiveness with repeated use. Before you pop the first pill, be very serious about getting ready to start these very potent meds. Use it as a one time shot to kick the candida back and then keep very strict to the diet, and natural antifungals until you feel like you are really doing well.